Generic Clozaril is used for managing schizophrenia in patients who do not respond to other medicines. It is also used to decrease the risk of suicidal behavior in certain patients.
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Clozapine tablet
What is this medicine?
CLOZAPINE is used to treat schizophrenia. This medicine is only used when others have not worked. It has a risk of serious side effects and is only available through a monitoring and dispensing system that includes special doctors, pharmacists, and laboratories. For the first few months of treatment, you will be required to have routine blood testing before your prescription can be refilled.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
being treated for cancer
blood disease or disorder, like leukemia
constipation, fecal impaction, or a history of an obstruction of the intestine
dementia
diabetes
heart disease
kidney disease
liver disease
low blood counts, like low white cell, platelet, or red cell counts
lung or breathing disease, like asthma
Parkinson's disease
phenylketonuria
seizures
an unusual or allergic reaction to clozapine, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
Take this medicine by mouth. This medicine may be taken with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not suddenly stop taking this medicine. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.
The tablets should stay in the unopened blister package until immediately before you take your dose. If you split the tablet as part of your dose, the half-tablet that is not taken should be destroyed. Do not save this half-tablet for later use.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. If you miss your medicine for more than 2 days, you should not restart your medicine at the same dose. Contact your doctor for instructions.
What may interact with this medicine?
Do not take this medicine with any of the following medications:
cisapride
medicines for treating cancer
mibefradil
olanzapine
phenothiazines like perphenazine, thioridazine and chlorpromazine
pimozide
ziprasidone
This medicine may also interact with the following medications:
caffeine
carbamazepine
cimetidine
ciprofloxacin
erythromycin or clarithromycin
lithium
medicines for anxiety or sleeping problems, such as diazepam or temazepam
medicines for colds, hay fever, and other allergies
medicines for high blood pressure
medicines for mental depression, anxiety, or other mood problems
nicotine
phenytoin
rifampin or rifabutin
some medicines used to treat irregular heartbeats
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects of this medicine. Contact your doctor or health care professional if your symptoms get worse or if you have new symptoms.
You must have a weekly blood test when you first begin this medicine. If your blood counts stay in the right range, your tests may be reduced after 6 months to every other week. Your name will go on a national registry of patients that take this medicine, to make sure that you have never had a serious reaction to it.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.
Do not treat yourself for colds, fever, diarrhea or allergies. Ask your doctor or health care professional for advice, some nonprescription medicines may increase possible side effects.
If you are going to have surgery tell your doctor or health care professional that you are taking this medicine.
If you have phenylketonuria, you should be aware that each 25 mg, orally-disintegrating tablet contains 3.1 mg of aspartame (1.74 mg of phenylalanine) and each 100 mg, orally-disintegrating tablet contains 12.4 mg of aspartame (6.96 mg of phenylalanine).
What side effects may I notice from this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breathing problems
changes in vision
chest pain, fast or irregular heartbeat
confusion
difficulty sleeping, nightmares
excessive thirst and/or hunger
feeling faint or lightheaded, falls
fever, chills, sore throat, or mouth sores
muscle and joint aches and pains
nausea, vomiting, or severe loss of appetite
restlessness
seizures
stiffness, spasms, trembling
trouble passing urine or change in the amount of urine
trouble with balance, talking, walking
uncontrollable tongue or chewing movements, smacking lips or puffing cheeks
unusually weak or tired
yellowing of the eyes, skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
constipation
dry mouth
headache
increased watering of the mouth, drooling
weight gain
This list may not describe all possible side effects.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep the tablets in the packaging until the time of use. Protect from moisture. Throw away any unused medicine after the expiration date.
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